Title : Long Chain Omega-3 Polyunsaturated Fatty Acid Supplementation Alleviates Doxorubicin-Induced Depressive-Like Behaviors and Neurotoxicity in Rats: Involvement of Oxidative Stress and Neuroinflammation.

Pub. Date : 2016 Apr 23

PMID : 27120616






1 Functional Relationships(s)
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1 Additionally, gene expression of pro-inflammatory cytokines, including IL-1beta, IL-6, and TNF-alpha, and the protein levels of NF-kappaB and iNOS were significantly increased in brain tissues of DOX-treated group, whereas omega-3 PUFAs supplementation significantly attenuated DOX-induced neuroinflammation. Doxorubicin nitric oxide synthase 2 Rattus norvegicus