Pub. Date : 2016 Jun
PMID : 27108888
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPARalpha. | ursolic acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 2 | Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, has been shown to upregulate PPARalpha in the peripheral tissues of obese animals. | ursolic acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 3 | Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, has been shown to upregulate PPARalpha in the peripheral tissues of obese animals. | ursolic acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 4 | The present study hypothesized that UA prevents augmented peripheral inflammation and inflammatory hyperalgesia in obesity by restoring downregulated spinal PPARalpha. | ursolic acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 5 | Additionally, UA normalized PPARalpha activity and inhibited the exaggerated spinal cord inflammatory response to carrageenan. | ursolic acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 6 | Although the knockdown of spinal PPARalpha with small interfering RNA following the administration of UA did not alter obesity or metabolic parameters, it eradicated the beneficial effects of UA on thermal hyperalgesia and paw edema, and reversed the spinal cord inflammatory response. | ursolic acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 7 | Although the knockdown of spinal PPARalpha with small interfering RNA following the administration of UA did not alter obesity or metabolic parameters, it eradicated the beneficial effects of UA on thermal hyperalgesia and paw edema, and reversed the spinal cord inflammatory response. | ursolic acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |
| 8 | These results suggested that the systemic administration of UA inhibited the exaggerated spinal cord inflammatory response to peripheral inflammatory stimulation in HFD-induced obesity by restoring downregulated spinal PPARalpha, preventing peripheral inflammation and inflammatory hyperalgesia. | ursolic acid | peroxisome proliferator activated receptor alpha | Rattus norvegicus |