Title : Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin.

Pub. Date : 2016 Jul 15

PMID : 27107943






1 Functional Relationships(s)
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1 Further analysis revealed that WWP1 ubiquitinated mHtt at an atypical position of Lys-63, which may have inhibited degradation of mutant Htt through the ubiquitin-proteasome pathway. Lysine huntingtin Mus musculus