Protein Name huntingtin
Organism Mus musculus
Gene ID 15194
Gene Symbol

Htt

UniProt G3X9H5 (G3X9H5_MOUSE)
Relationships Total Number of functionally related compound(s) : 257
Total Number of Articles : 692
Description

huntingtin

Gene Summary

Enables diazepam binding activity. Involved in several processes, including postsynapse to nucleus signaling pathway; regulation of cAMP-dependent protein kinase activity; and regulation of protein localization to nucleus. Acts upstream of or within several processes, including carboxylic acid metabolic process; positive regulation of cilium assembly; and transport along microtubule. Located in several cellular components, including centriole; inclusion body; and perinuclear region of cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system; retina; and testis. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (huntingtin). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • huntingtin
  • HD protein homolog
  • Huntington disease gene homolog
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Properties