| Protein Name | huntingtin |
|---|---|
| Organism | Mus musculus |
| Gene ID | 15194 |
| Gene Symbol | Htt |
| UniProt | G3X9H5 (G3X9H5_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
257
Total Number of Articles : 692 |
Description |
huntingtin |
| Gene Summary |
Enables diazepam binding activity. Involved in several processes, including positive regulation of CAMKK-AMPK signaling cascade; postsynapse to nucleus signaling pathway; and regulation of protein localization to nucleus. Acts upstream of or within several processes, including nervous system development; positive regulation of cilium assembly; and transport along microtubule. Located in several cellular components, including centriole; inclusion body; and perinuclear region of cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system; retina; and testis. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (huntingtin). [provided by Alliance of Genome Resources, Jul 2025] |
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