Pub. Date : 2016 Nov
PMID : 27106261
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: The numbers of IFN-gamma-releasing cells in allopurinol-allergic subjects were significantly higher than in control subjects when stimulating PBMCs with oxypurinol 100 mug mL-1 , especially when adding anti-PD-L1 supplementation. | Oxypurinol | interferon gamma | Homo sapiens |
| 2 | According to the receiver operating characteristic curve results, the optimal discriminatory power of IFN-gamma ELISpot in confirming diagnosis of allopurinol-induced SCARs can be obtained using 16 spot-forming cells per 106 PBMCs as a cut-off value upon oxypurinol/anti-PD-L1 stimulation (79 2% sensitivity and 95 2% specificity). | Oxypurinol | interferon gamma | Homo sapiens |
| 3 | CONCLUSIONS: The measurement of oxypurinol/anti-PD-L1-inducing IFN-gamma-releasing cells yields a high diagnostic value in distinguishing between allopurinol-allergic and control subjects. | Oxypurinol | interferon gamma | Homo sapiens |