Pub. Date : 2016 Apr 21
PMID : 27098390
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol enhances HBV replication through activating Sirt1-PGC-1alpha-PPARalpha pathway. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 2 | We found that RSV activates Sirt1, which in turn deacetylates PGC-1alpha and subsequently increases the transcriptional activity of PPARalpha, leading to the enhanced HBV transcription and replication in vitro and in vivo. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 3 | Taken together, this study identifies that RSV enhances HBV transcription and replication especially acting on the core promoter, which depends on Sirt1-PGC-1alpha-PPARalpha pathway. | Resveratrol | peroxisome proliferator activated receptor alpha | Homo sapiens |