Pub. Date : 2016 Jun
PMID : 27089389
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tolfenamic acid downregulates beta-catenin in colon cancer. | tolfenamic acid | catenin beta 1 | Homo sapiens |
| 2 | The current study investigates the role of tolfenamic acid on beta-catenin expression in colon cancer. | tolfenamic acid | catenin beta 1 | Homo sapiens |
| 3 | Treatment with tolfenamic acid led to inhibition of cell growth and down-regulation of beta-catenin expression in a dose- and time-dependent manner in human colon cancer cell lines. | tolfenamic acid | catenin beta 1 | Homo sapiens |
| 4 | Reduction of beta-catenin upon tolfenamic acid treatment was associated with ubiquitin-mediated proteasomal degradation, without affecting mRNA level and promoter activity of beta-catenin. | tolfenamic acid | catenin beta 1 | Homo sapiens |
| 5 | In addition, treatment with tolfenamic acid downregulated Smad2 and Smad3 expression, while overexpression of Smad2, but not Smad3, blocked tolfenamic acid-induced suppression of beta-catenin expression. | tolfenamic acid | catenin beta 1 | Homo sapiens |
| 6 | Tolfenamic acid also decreased expression of beta-catenin target genes, including vascular endothelial growth factor (VEGF). | tolfenamic acid | catenin beta 1 | Homo sapiens |
| 7 | In conclusion, our findings suggest that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2 and, subsequently, facilitating ubiquitin-proteasome-mediated beta-catenin degradation in colon cancer. | tolfenamic acid | catenin beta 1 | Homo sapiens |