Pub. Date : 2016 May 31
PMID : 27083050
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reduction of microRNA-184 by E6 oncoprotein confers cisplatin resistance in lung cancer via increasing Bcl-2. | Cisplatin | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Bcl-2 de-targeted by E6-mediated miR- 184 reduction was responsible for cisplatin resistance. | Cisplatin | BCL2 apoptosis regulator | Homo sapiens |
| 3 | Patients with low-mR-184, E6-positive, high-Bcl-2 tumors, and both combinations were more prevalently occurred unfavorable response to cisplatin-based chemotherapy than their counterparts. | Cisplatin | BCL2 apoptosis regulator | Homo sapiens |
| 4 | In conclusion, a decrease in miR-184 level by E6 oncoprotein may predict unfavorable response to cisplatin-based chemotherapy in HPV-infected NSCLC patients via increasing Bcl-2 expression. | Cisplatin | BCL2 apoptosis regulator | Homo sapiens |