Pub. Date : 2016 Apr 14
PMID : 27075683
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, we investigated whether oral administration of sulforaphane (SFN) prevented high-fat diet-induced NAFLD in mice by regulation of the NLRP3 inflammasome in the liver. | sulforaphane | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | Therefore, we investigated whether oral administration of sulforaphane (SFN) prevented high-fat diet-induced NAFLD in mice by regulation of the NLRP3 inflammasome in the liver. | sulforaphane | NLR family, pyrin domain containing 3 | Mus musculus |
| 3 | These were correlated with the suppression of NLRP3 inflammasome activation in the liver by SFN as evidenced by decrease in mRNA levels of ASC and caspase-1, caspase-1 enzyme activity, and IL-1beta levels. | sulforaphane | NLR family, pyrin domain containing 3 | Mus musculus |
| 4 | SFN inhibited saturated fatty acid-induced activation of the NLRP3 inflammasome in primary mouse hepatocytes, accompanied by the restoration of mitochondrial dysfunction. | sulforaphane | NLR family, pyrin domain containing 3 | Mus musculus |
| 5 | The suppression of NLRP3 inflammasome by SFN was mediated by the regulation of AMP-activated protein kinase-autophagy axis. | sulforaphane | NLR family, pyrin domain containing 3 | Mus musculus |