Title : Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling.

Pub. Date : 2016 Apr 26

PMID : 27071101






1 Functional Relationships(s)
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1 OX-A is crucial for the control of wakefulness and energy homeostasis and promotes, in OX-1R-expressing cells, the biosynthesis of the endogenous counterpart of marijuana"s psychotropic and appetite-inducing component Delta(9)-tetrahydrocannabinol, i.e., the endocannabinoid 2-arachidonoylglycerol (2-AG), which acts at CB1R. Dronabinol cannabinoid receptor 1 (brain) Mus musculus