Pub. Date : 2017 Jan
PMID : 27056295
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In rats, pretreatment with either dehydroepiandrosterone or fluvoxamine, a high-affinity sigma1-receptor agonist, improved survival, renal function and structure, and the inflammatory response after sublethal renal ischemia-reperfusion injury. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 2 | In human proximal tubular epithelial cells, stimulation by fluvoxamine or oxidative stress caused the sigma1-receptor to translocate from the endoplasmic reticulum to the cytosol and nucleus. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 3 | Fluvoxamine stimulation in these cells also activated nitric oxide production that was blocked by sigma1-receptor knockdown or Akt inhibition. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 4 | Similarly, in the postischemic rat kidney, sigma1-receptor activation by fluvoxamine triggered the Akt-nitric oxide synthase signaling pathway, resulting in time- and isoform-specific endothelial and neuronal nitric oxide synthase activation and nitric oxide production. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |
| 5 | Concurrently, intravital two-photon imaging revealed prompt peritubular vasodilation after fluvoxamine treatment, which was blocked by the sigma1-receptor antagonist or various nitric oxide synthase blockers. | Fluvoxamine | sigma non-opioid intracellular receptor 1 | Rattus norvegicus |