Pub. Date : 2016 Mar
PMID : 27047993
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that chloroquine and resveratrol, both known ATM activators, would also activate AMPK and Akt. | Chloroquine | ATM serine/threonine kinase | Homo sapiens |
| 2 | Chloroquine also increased autophosphorylation of ATM by ~50% (P<0.05). | Chloroquine | ATM serine/threonine kinase | Homo sapiens |
| 3 | Chloroquine increased AMPK and Akt phosphorylation in myotubes expressing shRNA against ATM that reduced ATM protein levels by about 90%. | Chloroquine | ATM serine/threonine kinase | Homo sapiens |
| 4 | Chloroquine increased AMPK and Akt phosphorylation in myotubes expressing shRNA against ATM that reduced ATM protein levels by about 90%. | Chloroquine | ATM serine/threonine kinase | Homo sapiens |
| 5 | SIGNIFICANCE: These ATM-independent effects of chloroquine on AMPK and Akt and the additional effect to decrease intracellular calcium are likely to partially underlie the positive metabolic effects of chloroquine that have been reported in the literature. | Chloroquine | ATM serine/threonine kinase | Homo sapiens |
| 6 | SIGNIFICANCE: These ATM-independent effects of chloroquine on AMPK and Akt and the additional effect to decrease intracellular calcium are likely to partially underlie the positive metabolic effects of chloroquine that have been reported in the literature. | Chloroquine | ATM serine/threonine kinase | Homo sapiens |