PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27047993-2 2016 We hypothesized that chloroquine and resveratrol, both known ATM activators, would also activate AMPK and Akt. Chloroquine 21-32 ATM serine/threonine kinase Homo sapiens 61-64 27047993-7 2016 Chloroquine also increased autophosphorylation of ATM by ~50% (P<0.05). Chloroquine 0-11 ATM serine/threonine kinase Homo sapiens 50-53 27047993-9 2016 Chloroquine increased AMPK and Akt phosphorylation in myotubes expressing shRNA against ATM that reduced ATM protein levels by about 90%. Chloroquine 0-11 ATM serine/threonine kinase Homo sapiens 88-91 27047993-9 2016 Chloroquine increased AMPK and Akt phosphorylation in myotubes expressing shRNA against ATM that reduced ATM protein levels by about 90%. Chloroquine 0-11 ATM serine/threonine kinase Homo sapiens 105-108 27047993-12 2016 SIGNIFICANCE: These ATM-independent effects of chloroquine on AMPK and Akt and the additional effect to decrease intracellular calcium are likely to partially underlie the positive metabolic effects of chloroquine that have been reported in the literature. Chloroquine 47-58 ATM serine/threonine kinase Homo sapiens 20-23 27047993-12 2016 SIGNIFICANCE: These ATM-independent effects of chloroquine on AMPK and Akt and the additional effect to decrease intracellular calcium are likely to partially underlie the positive metabolic effects of chloroquine that have been reported in the literature. Chloroquine 202-213 ATM serine/threonine kinase Homo sapiens 20-23