Title : The Interactions of P-Glycoprotein with Antimalarial Drugs, Including Substrate Affinity, Inhibition and Regulation.

Pub. Date : 2016

PMID : 27045516






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mefloquine was shown to be a P-gp inhibitor affecting our P-gp substrate, Rhodamine 123, although none of the other drugs impacted upon rhodamine123 transport rates. Mefloquine ATP binding cassette subfamily B member 1 Homo sapiens
2 Mefloquine was shown to be a P-gp inhibitor affecting our P-gp substrate, Rhodamine 123, although none of the other drugs impacted upon rhodamine123 transport rates. Mefloquine ATP binding cassette subfamily B member 1 Homo sapiens
3 In conclusion, mefloquine is a P-gp inhibitor and methylene blue is a partial substrate; methylene blue may have increased absorption if co-administered with such P-gp inhibitors. Mefloquine ATP binding cassette subfamily B member 1 Homo sapiens
4 In conclusion, mefloquine is a P-gp inhibitor and methylene blue is a partial substrate; methylene blue may have increased absorption if co-administered with such P-gp inhibitors. Mefloquine ATP binding cassette subfamily B member 1 Homo sapiens
5 An upregulation of P-gp was observed when artemisone and dihydroartemisinin were co-incubated with mefloquine and amodiaquine. Mefloquine ATP binding cassette subfamily B member 1 Homo sapiens