Pub. Date : 2016 Apr 1
PMID : 27036297
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Naringenin prevents TGF-beta1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. | naringenin | transforming growth factor, beta 1 | Mus musculus |
| 2 | We have previously demonstrated that naringenin significantly reduced TGF-beta1 levels in bleomycin-induced lung fibrosis and effectively prevented pulmonary metastases of tumors. | naringenin | transforming growth factor, beta 1 | Mus musculus |
| 3 | This raised the question of whether naringenin can block TGF-beta1 secretion from breast cancer cells and inhibit their pulmonary metastasis. | naringenin | transforming growth factor, beta 1 | Mus musculus |
| 4 | The mechanism whereby naringenin decreases TGF-beta1 secretion from breast cancer cells was investigated at different levels, including Tgf-beta1 transcription, mRNA stability, translation, and extracellular release. | naringenin | transforming growth factor, beta 1 | Mus musculus |
| 5 | Administration of the TGF-beta1 blocking antibody 1D11 or naringenin showed an inhibition of pulmonary metastasis for both 4T1/TGF-beta1 tumors and 4T1/RFP tumors, resulting in increased survival of the mice. | naringenin | transforming growth factor, beta 1 | Mus musculus |
| 6 | Further experiments revealed that naringenin had no effect on Tgf-beta1 transcription, mRNA decay or protein translation, but prevented TGF-beta1 transport from the trans-Golgi network by inhibiting PKC activity. | naringenin | transforming growth factor, beta 1 | Mus musculus |
| 7 | CONCLUSIONS: Naringenin blocks TGF-beta1 trafficking from the trans-Golgi network by suppressing PKC activity, resulting in a reduction of TGF-beta1 secretion from breast cancer cells. | naringenin | transforming growth factor, beta 1 | Mus musculus |
| 8 | CONCLUSIONS: Naringenin blocks TGF-beta1 trafficking from the trans-Golgi network by suppressing PKC activity, resulting in a reduction of TGF-beta1 secretion from breast cancer cells. | naringenin | transforming growth factor, beta 1 | Mus musculus |
| 9 | This finding suggests that naringenin may be an attractive therapeutic candidate for TGF-beta1 related diseases. | naringenin | transforming growth factor, beta 1 | Mus musculus |