Title : Nuclear respiratory factor 1 overexpression attenuates anti-benzopyrene‑7,8-diol-9,10-epoxide-induced S-phase arrest of bronchial epithelial cells.

Pub. Date : 2016 May

PMID : 27035420






1 Functional Relationships(s)
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1 In the present study, it was observed that its genotoxic metabolite, anti-benzopyrene-7,8-diol-9,10-epoxide (BPDE), triggered cell cycle arrest in S-phase in 16HBE cells by activating ataxia-telangiectasia (ATM)/checkpoint kinase (Chk)2 and ATM and Rad3 related (ATR)/Chk1 signaling pathways. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide checkpoint kinase 1 Homo sapiens