Title : Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II.

Pub. Date : 2016 Jun

PMID : 27031052






2 Functional Relationships(s)
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1 The cAMP-dependent PKA activity of prazosin-stimulated hepatocytes was suppressed by a phospholipase C (PLC) inhibitor (U-73122), trifluoperazine, and a CaMK-II inhibitor (KN-93). Prazosin protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
2 CONCLUSIONS: These results suggested that prazosin-stimulated HTGL release from hepatocytes was caused by activation of PKA associated with stimulation of CaMK-II activity through a signal cascade from PLC. Prazosin protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus