Title : Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation.

Pub. Date : 2016 Mar 29

PMID : 27026438






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The HMGB1-DNA complex binds to RAGE on neighboring cells and then CpG DNA is recognized by TLR9 in lysosomes, leading to generation of nitric oxide and 8-nitroG formation. Nitric Oxide high mobility group box 1 Homo sapiens