Pub. Date : 2016 Jun
PMID : 27026405
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | In this study, we characterize the role of curcumin in the cytotoxicity, p38 MAPK activation, and XRCC1 expression affected by cisplatin in NSCLC cells. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Treatment with cisplatin alone increased XRCC1 mRNA and protein expression through p38 MAPK activation. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | Moreover, SB2023580 (p38 inhibitor) decreased the XRCC1 mRNA and protein stability upon cisplatin treatment. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | Knockdown of XRCC1 in NSCLC cells by transfection of XRCC1 siRNA or inactivation of p38 MAPK resulted in enhancing the cytotoxicity and cell growth inhibition induced by cisplatin. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |