Title : Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1.

Pub. Date : 2016 Jun 1

PMID : 27020609






4 Functional Relationships(s)
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1 Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFbeta, and IDO1. Kynurenine aryl-hydrocarbon receptor Mus musculus
2 At physiological levels, kynurenine but not kynurenic acid (both tryptophan metabolites and known AHR agonists) activated AHR-directed luciferase expression. Kynurenine aryl-hydrocarbon receptor Mus musculus
3 We propose a hepatocyte-based model, in which kynurenine production is increased by enhanced IDO1 activity stimulated by TGFbeta1 and TLR2/4 signaling, via PI3K and NF-kappaB, to perpetuate a cycle of AHR activation to cause obesity; and inhibition of the AHR, in turn, blocks the cycle"s output to prevent obesity. Kynurenine aryl-hydrocarbon receptor Mus musculus
4 We propose a hepatocyte-based model, in which kynurenine production is increased by enhanced IDO1 activity stimulated by TGFbeta1 and TLR2/4 signaling, via PI3K and NF-kappaB, to perpetuate a cycle of AHR activation to cause obesity; and inhibition of the AHR, in turn, blocks the cycle"s output to prevent obesity. Kynurenine aryl-hydrocarbon receptor Mus musculus