Pub. Date : 2016 Jun 10
PMID : 27019345
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The models were used to simulate inhibition of the MATE1, MATE2-K, OCT1 and OCT2 mediated transport of metformin by cimetidine. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 2 | An alternative description of metformin renal transport by OCT1 and OCT2, incorporating electrochemical modulation of the rate of metformin uptake together with 8-18-fold decreases in cimetidine Ki"s for OCTs and MATEs, allowed recovery of the extent of the observed effect of cimetidine on metformin AUC. | Metformin | solute carrier family 22 member 1 | Homo sapiens |