Pub. Date : 2016 Apr 26
PMID : 27004400
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin. | Erlotinib Hydrochloride | amphiregulin | Homo sapiens |
| 2 | Knockdown of AREG in HNSCC cells harboring MAPK1E322K abrogated EGFR signaling and decreased sensitivity to erlotinib in vitro and in vivo. | Erlotinib Hydrochloride | amphiregulin | Homo sapiens |
| 3 | These cumulative findings implicate increased AREG secretion and EGFR activation as contributing to increased erlotinib sensitivity in MAPK1E322K HNSCC. | Erlotinib Hydrochloride | amphiregulin | Homo sapiens |