PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27004400-0	2016	MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin.	Erlotinib Hydrochloride	83-92	amphiregulin	Homo sapiens	123-135	
27004400-8	2016	Knockdown of AREG in HNSCC cells harboring MAPK1E322K abrogated EGFR signaling and decreased sensitivity to erlotinib in vitro and in vivo.	Erlotinib Hydrochloride	108-117	amphiregulin	Homo sapiens	13-17	
27004400-9	2016	These cumulative findings implicate increased AREG secretion and EGFR activation as contributing to increased erlotinib sensitivity in MAPK1E322K HNSCC.	Erlotinib Hydrochloride	110-119	amphiregulin	Homo sapiens	46-50