Title : Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation.

Pub. Date : 2016 Mar 22

PMID : 27000430






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Uniquely within the NMDA receptor family, GluN1/GluN3 receptors produce glycine-gated deeply desensitising currents that are insensitive to glutamate and NMDA; these currents remain poorly characterised and their cellular functions are unknown. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
2 Here, we show that extracellular acidification strongly potentiated glycine-gated currents from recombinant GluN1/GluN3A receptors, with half-maximal effect in the physiologic pH range. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens