Pub. Date : 2016 Mar
PMID : 26997994
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, treatment with DEX significantly reduced serum expression levels of IL-6, IL-8 and TNF-alpha and decreased expression levels of NF-kappaB, JAK2 and STAT3 in the lung tissue, as compared with the untreated SAP group. | Dexamethasone | Janus kinase 2 | Rattus norvegicus |
| 2 | The present study demonstrated that DEX treatment was able to suppress ICAM-1 mRNA and protein expression in a rat model of SAP-ALI via the inhibition of IL-6 and TNF-alpha-induced JAK2/STAT3 activation; thus suggesting that DEX treatment may be considered a potential strategy in the treatment of patients with SAP-ALI. | Dexamethasone | Janus kinase 2 | Rattus norvegicus |