Title : BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death.

Pub. Date : 2016 Apr 26

PMID : 26993765






3 Functional Relationships(s)
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1 We have shown previously that NF-kappaB inhibitor BAY 11-7085, through inactivation of PPAR-gamma, induces apoptosis in human synovial fibroblasts. BAY 11-7085 peroxisome proliferator activated receptor gamma Homo sapiens
2 Both BAY 11-7085-induced autophagy and GR activation were down regulated with PPAR-gamma agonist, 15d-PGJ2 and MEK/ERK inhibitor UO126. BAY 11-7085 peroxisome proliferator activated receptor gamma Homo sapiens
3 These results showed that GR activation and PPAR-gamma inactivation mediated BAY 11-7085-induced autophagy. BAY 11-7085 peroxisome proliferator activated receptor gamma Homo sapiens