Pub. Date : 2016 Mar 17
PMID : 26988982
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Our results showed that IL-17A increased COX2 expression and PGE2 production via the activation of MAPKs, including p38 kinase and Jun N-terminal kinase (JNK). | Dinoprostone | interleukin 17A | Homo sapiens |
| 2 | Moreover, IL-17A-induced COX2 and PGE2 production was shown to rely on p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner. | Dinoprostone | interleukin 17A | Homo sapiens |
| 3 | CONCLUSION: In summary, our results indicate that IL-17A enhances COX2 expression and PGE2 production via the p38/c-Fos and JNK/c-Jun signalling pathways in NP cells to mediate IVD inflammation. | Dinoprostone | interleukin 17A | Homo sapiens |