Pub. Date : 2016 Apr
PMID : 26980429
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol, an NF-kappaB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis. | celastrol | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | In this study, therefore, we evaluated the role of celastrol, an NF-kappaB inhibitor, in a mouse model of secondary osteoporosis. | celastrol | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | Moreover, other important events were observed after celastrol treatment, covering substantial decrements in serum concentrations of PTH, TRAP-5b, CTX and DPD, improved structure of articular cartilage and cancellous bone (revealed by H&E and safranin-O staining), and significant decline in levels of NF-kappaB (P65), MMP-1, and MMP-9. | celastrol | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |