Title : Phospholamban degradation is induced by phosphorylation-mediated ubiquitination and inhibited by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase.

Pub. Date : 2016 Apr 8

PMID : 26966065






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phospholamban (PLN) regulates cardiac type sarco (endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) via Ser(16)-phosphorylation. Serine phospholamban Mus musculus
2 These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys(3) and degraded through Ser(16)-phosphorylation-mediated poly-ubiquitination during heart failure. Serine phospholamban Mus musculus