Pub. Date : 2016 Mar 15
PMID : 26943970
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism. | Cholecalciferol | interleukin 10 | Homo sapiens |
| 2 | Most importantly, the activated microglia exposed to vitamin D3 had reduced expression of pro-inflammatory cytokines, IL-6, IL-12, and TNFalpha, and increased expression of IL-10. | Cholecalciferol | interleukin 10 | Homo sapiens |
| 3 | Therefore, vitamin D3 increases the expression of IL-10 creating a feedback loop via SOCS3 that downregulates the pro-inflammatory immune response by activated microglia which would likewise prevent immune mediated damage in the CNS. | Cholecalciferol | interleukin 10 | Homo sapiens |