Pub. Date : 2016
PMID : 26938432
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot analysis demonstrated the activation of Akt, Erk and upregulation of PCNA in HaCaT cells treated with 17 beta-estradiol. | Estradiol | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Upregulation of PCNA expression, elevated proliferation and high S phase fraction of HaCaT cell by 17 beta-estradiol could be reversed by an Akt or Erk inhibitor. | Estradiol | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Moreover, Erk inhibition reversed 17 beta-estradiol-induced Akt activation, whereas an Akt inhibitor exhibited no effect on Erk, further suggesting that Erk was on the upstream while Akt on the downstream of the signaling pathway. | Estradiol | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | CONCLUSION: This study demonstrates that one of the critical mechanisms underlying 17 beta-estradiol promoting skin wound healing is through regulation of keratinocyte proliferation via Erk/Akt signaling pathway. | Estradiol | mitogen-activated protein kinase 1 | Homo sapiens |