Title : Thiopurine Biotransformation and Pharmacological Effects: Contribution of Oxidative Stress.

Pub. Date : 2016

PMID : 26935390






1 Functional Relationships(s)
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1 Interestingly, recent genome-wide association studies have shown that, for both azathioprine in inflammatory bowel disease and mercaptopurine in acute lymphoblastic leukemia, treatment effects on patients" white blood cells are related to variants of a gene, NUDT15, involved in biotransformation of oxidated nucleotides. Azathioprine nudix hydrolase 15 Homo sapiens