Pub. Date : 2016 May
PMID : 26935193
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we investigated flavone (the core structure of flavonoids)-induced regulation on ROS generation and DLC1/RhoA pathway in MCF-7 and MDA-MB-231 breast cancer cells and explored whether flavone-induced upregulation of DLC1 is mediated by ROS. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 2 | Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 3 | In this study, we investigated flavone (the core structure of flavonoids)-induced regulation on ROS generation and DLC1/RhoA pathway in MCF-7 and MDA-MB-231 breast cancer cells and explored whether flavone-induced upregulation of DLC1 is mediated by ROS. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 4 | Our results showed that flavone decreased ROS production and inhibited cell migration through DLC1/RhoA pathway. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 5 | To further investigate the role of ROS in flavone-induced regulation on DLC1/RhoA pathway, hydrogen peroxide was added to restore the ROS levels. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 6 | Flavone-induced upregulation of DLC1 expression, downregulation of RhoA activity, and inhibition of cell migration were all restrained by hydrogen peroxide. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 7 | We also found that flavone increased DLC1 stability by inhibiting DLC1 protein degradation in breast cancer cells. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 8 | We also found that flavone increased DLC1 stability by inhibiting DLC1 protein degradation in breast cancer cells. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 9 | In summary, our study demonstrated that flavone inhibited cell migration through DLC1/RhoA pathway by decreasing ROS generation and suppressed DLC1 degradation in MCF-7 and MDA-MB-231 breast cancer cells. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |
| 10 | In summary, our study demonstrated that flavone inhibited cell migration through DLC1/RhoA pathway by decreasing ROS generation and suppressed DLC1 degradation in MCF-7 and MDA-MB-231 breast cancer cells. | flavone | DLC1 Rho GTPase activating protein | Homo sapiens |