Protein Name DLC1 Rho GTPase activating protein
Organism Homo sapiens
Gene ID 10395
Gene Symbol

DLC1

UniProt Q96QB1 (RHG07_HUMAN), A8K119 (A8K119_HUMAN)
Relationships Total Number of functionally related compound(s) : 52
Total Number of Articles : 73
Description

DLC1 Rho GTPase activating protein

Gene Summary

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

synonyms
  • rho GTPase-activating protein 7
  • Rho-GTPase-activating protein 7
  • START domain-containing protein 12
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Properties