Title : Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.

Pub. Date : 2016 Mar 29

PMID : 26934645






1 Functional Relationships(s)
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1 Therefore, we propose targeting androgen-independent prostate cancer cells with compounds that affect Des1/SK1 to modulate both de novo and sphingolipid rheostat pathways in order to induce growth arrest. Sphingolipids delta 4-desaturase, sphingolipid 1 Homo sapiens