Title : The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices.

Pub. Date : 2016 May

PMID : 26932816






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Dual inhibitors of both P-gp and Cyp3a (verapamil and ketoconazole) increased the concentration of Qi in the jejunum and ileum, but less 3-hydroxy-quinidine was produced due to inhibition of Cyp3a. Verapamil ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus