Pub. Date : 2016 Apr
PMID : 26922123
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous studies have demonstrated that intramedullary inhibition of heme oxygenase-1 (HO-1) increases the blood pressure and superoxide production response to angiotensin II (Ang II) infusion. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 2 | Previous studies have demonstrated that intramedullary inhibition of heme oxygenase-1 (HO-1) increases the blood pressure and superoxide production response to angiotensin II (Ang II) infusion. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 3 | The present study was designed to test the hypothesis that increased renal medullary superoxide production contributes to the increase in blood pressure in response to blockade of renal medullary HO-1 in Ang II-induced hypertension. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 4 | Renal medullary superoxide production in Ang II-treated mice was significantly increased by infusion of QC-13 alone. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 5 | These results demonstrate that renal medullary interstitial blockade of HO-1 exacerbates Ang II-induced hypertension via a mechanism that is dependent on enhanced superoxide generation and highlight the important antioxidant function of HO-1 in the renal medulla. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |