Title : Effects of iron overload condition on liver toxicity and hepcidin/ferroportin expression in thalassemic mice.

Pub. Date : 2016 Apr 1

PMID : 26921633






2 Functional Relationships(s)
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1 This study aimed to investigate the roles of L-type calcium channels (LTCC), T-type calcium channels (TTCC) and divalent metal transporter1 (DMT1) in iron-mediated hepatic injury in HT mice. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
2 KEY FINDINGS: TTCC and DMT1 blockers and DFO decreased liver iron and malondialdehyde (MDA) in HT mice indicating their antioxidant effects, whereas LTCC blocker produced no decrease in liver iron or MDA. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus