Pub. Date : 2016 Mar 24
PMID : 26918322
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytochrome P450 CYP26 enzymes are responsible for all-trans-retinoic acid (atRA) clearance. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 2 | Cytochrome P450 CYP26 enzymes are responsible for all-trans-retinoic acid (atRA) clearance. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 3 | Inhibition of CYP26 enzymes will increase endogenous atRA concentrations and is an attractive therapeutic target. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 4 | However, the selectivity and potency of the existing atRA metabolism inhibitors toward CYP26A1 and CYP26B1 is unknown, and no selective CYP26A1 or CYP26B1 inhibitors have been developed. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |