Pub. Date : 2016 Feb 23
PMID : 26902888
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Here, we demonstrate that resveratrol induces autophagy by directly inhibiting the mTOR-ULK1 pathway. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | We found that inhibition of mTOR activity and presence of ULK1 are required for autophagy induction by resveratrol. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | In line with this mTOR dependency, we found that resveratrol suppresses the viability of MCF7 cells but not of SW620 cells, which are mTOR inhibitor sensitive and insensitive cancer cells, respectively. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | In line with this mTOR dependency, we found that resveratrol suppresses the viability of MCF7 cells but not of SW620 cells, which are mTOR inhibitor sensitive and insensitive cancer cells, respectively. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 6 | For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 7 | For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 8 | For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 9 | For the mechanism of action of resveratrol on mTOR inhibition, we demonstrate that resveratrol directly inhibits mTOR. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 10 | We found that resveratrol inhibits mTOR by docking onto the ATP-binding pocket of mTOR (i.e., it competes with ATP). | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 11 | We found that resveratrol inhibits mTOR by docking onto the ATP-binding pocket of mTOR (i.e., it competes with ATP). | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 12 | We propose mTOR as a novel direct target of resveratrol, and inhibition of mTOR is necessary for autophagy induction. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |