Title : Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling.

Pub. Date : 2016 Aug

PMID : 26894601






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Interestingly, blockage of GLS1 with a selective inhibitor, CB839, or siRNA dramatically sensitized the PP242-induced cell death, as evident from increased PARP cleavage. PP242 glutaminase Homo sapiens
2 The anti-cancer activity of CB-839 and PP242 was abrogated by the addition of the TCA cycle product alpha-ketoglutarate, indicating the critical function of GLS1 in ovarian cancer cell survival. PP242 glutaminase Homo sapiens