Protein Name glutaminase
Organism Homo sapiens
Gene ID 2744
Gene Symbol

GLS

UniProt O94925 (GLSK_HUMAN), Q68D38 (Q68D38_HUMAN)
Relationships Total Number of functionally related compound(s) : 297
Total Number of Articles : 357
Description

glutaminase

Gene Summary

This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

synonyms
  • glutaminase kidney isoform, mitochondrial
  • K-glutaminase
  • L-glutamine amidohydrolase
Click to show/hide the synonyms
Properties