Title : Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages.

Pub. Date : 2016 May

PMID : 26893256






2 Functional Relationships(s)
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1 Immunoblotting showed that the oxysterol activated the ER transmembrane resident kinases of IRE1alpha, PERK and ATF4 and triggered caspase-12 signaling cascades, which was reversed by alpha-asarone. Oxysterols activating transcription factor 4 Mus musculus
2 Finally, alpha-asarone disturbed oxysterol-elicited signaling of PERK and ATF4 responsible for CHOP induction. Oxysterols activating transcription factor 4 Mus musculus