| Protein Name | activating transcription factor 4 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11911 |
| Gene Symbol | Atf4 |
| UniProt | Q06507 (ATF4_MOUSE), Q8CF69 (Q8CF69_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
213
Total Number of Articles : 271 |
Description |
activating transcription factor 4 |
| Gene Summary |
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and cAMP response element binding protein binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including cellular response to leucine starvation; intracellular signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including gluconeogenesis; positive regulation of sodium-dependent phosphate transport; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025] |
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