Title : Angiotensin II-mediated hypertension impairs nitric oxide-induced NKCC2 inhibition in thick ascending limbs.

Pub. Date : 2016 Apr 15

PMID : 26887831






2 Functional Relationships(s)
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1 In other cell types, ANG II augments phosphodiesterase 5 (PDE5)-mediated cGMP degradation. Cyclic GMP angiotensinogen Rattus norvegicus
2 We hypothesized that NO-mediated inhibition of NKCC2 activity and stimulation of cGMP synthesis are blunted via PDE5 in ANG II-induced hypertension. Cyclic GMP angiotensinogen Rattus norvegicus