Pub. Date : 2016 Mar 8
PMID : 26885898
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling. | Metformin | sirtuin 1 | Homo sapiens |
| 2 | In this present study, we confirmed that metformin enhanced SIRT1 and AMPK expression in human umbilical vein endothelial cells (HUVECs). | Metformin | sirtuin 1 | Homo sapiens |
| 3 | However, silencing SIRT1 and AMPK diminished the protective function of metformin against oxidative injuries. | Metformin | sirtuin 1 | Homo sapiens |