PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26885449-4 2015 We found that metformin suppressed HSY cell growth in vitro in a time and dose dependent manner associated with a reduced expression of MYC onco-protein, and the same inhibitory effect of metformin was also confirmed in HSG cells. Metformin 14-23 MYC proto-oncogene, bHLH transcription factor Homo sapiens 136-139 26885449-5 2015 In association with the reduction of MYC onco-protein, metformin significantly restored p53 tumor suppressor gene expression. Metformin 55-64 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-40 26885449-6 2015 The distinctive effects of metformin and PP242 on MYC reduction and P53 restoration suggested that metformin inhibited cell growth through a different pathway from PP242 in salivary carcinoma cells. Metformin 99-108 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-53