Title : Nicotine enhances hepatocyte growth factor-mediated lung cancer cell migration by activating the α7 nicotine acetylcholine receptor and phosphoinositide kinase-3-dependent pathway.

Pub. Date : 2016 Jan

PMID : 26870265






3 Functional Relationships(s)
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1 Nicotine did not induce Akt phosphorylation by itself, but instead promoted the HGF-induced phosphorylation of Akt. Nicotine AKT serine/threonine kinase 1 Homo sapiens
2 Nicotine did not induce Akt phosphorylation by itself, but instead promoted the HGF-induced phosphorylation of Akt. Nicotine AKT serine/threonine kinase 1 Homo sapiens
3 The current study provides an insight into the mechanism of tumor promotion by demonstrating that nicotine and alpha7-nAchRs act in synergy with the HGF-induced PI3K/Akt signaling pathway, increasing the sensitivity of lung cancer cells to HGF, and thereby promoting cell migration, a vital step in invasion and metastasis. Nicotine AKT serine/threonine kinase 1 Homo sapiens