Pub. Date : 2016 Apr 15
PMID : 26867495
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites. | NAD | myeloperoxidase | Homo sapiens |
| 2 | The role of neutrophil myeloperoxidase (MPO) in INH-NAD(+) adduct formation has never been explored; this is important, as neutrophils are recruited at the site of tuberculosis infection (granuloma) through infected macrophages" cell death signals. | NAD | myeloperoxidase | Homo sapiens |
| 3 | MPO or activated human neutrophils (by phorbol myristate acetate) catalyzed the oxidation of INH and formed several free radical intermediates; the inclusion of superoxide dismutase revealed a carbon-centered radical which is considered to be the reactive metabolite that binds with NAD(+). | NAD | myeloperoxidase | Homo sapiens |
| 4 | Furthermore, only INH oxidation by MPO led to a new product (lambdamax=326nm) in the presence of NAD(+). | NAD | myeloperoxidase | Homo sapiens |