Pub. Date : 2016 May 1
PMID : 26862121
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity. | Doxorubicin | ataxia telangiectasia mutated | Mus musculus |
| 2 | Here, we show that ATM in cardiac fibroblasts is essential for Dox-induced cardiotoxicity. | Doxorubicin | ataxia telangiectasia mutated | Mus musculus |
| 3 | METHODS AND RESULTS: ATM knockout mice showed attenuated Dox-induced cardiotoxic effects (e.g. cardiac dysfunction, apoptosis, and mortality). | Doxorubicin | ataxia telangiectasia mutated | Mus musculus |
| 4 | Therapeutically, a potent and selective inhibitor of ATM, KU55933, when administered systemically was able to prevent Dox-induced cardiotoxicity. | Doxorubicin | ataxia telangiectasia mutated | Mus musculus |
| 5 | CONCLUSION: ATM-regulated effects within cardiac fibroblasts are pivotal in Dox-induced cardiotoxicity, and antagonism of ATM and its functions may have potential therapeutic implications. | Doxorubicin | ataxia telangiectasia mutated | Mus musculus |